drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Human afucosylated IgG1 monoclonal antibody (AMG 451; KHK4083) administered subcutaneously that targets OX40 (TNFRSF4) on activated T cells, blocking OX40–OX40L co-stimulatory signaling and mediating ADCC to deplete OX40+ T cells, thereby reducing T-cell activation, survival, and memory and attenuating type 2 inflammation.
nci_thesaurus_concept_id
C184936
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Human afucosylated IgG1 monoclonal antibody targeting OX40 (TNFRSF4) on activated T cells; blocks OX40–OX40L co-stimulatory signaling and leverages enhanced ADCC to deplete OX40+ effector/memory T cells, reducing T-cell activation, survival, and type 2 inflammatory responses.
drug_name
Rocatinlimab
nct_id_drug_ref
NCT05704738