drug_type
RELEVANT_DRUG
intervention_type
Vaccine (plasmid DNA)
drug_description
An intradermal plasmid DNA cancer vaccine encoding Th1-biased polyepitopes from CDH3 (P-cadherin), CD105 (endoglin), YB-1, MDM2, and SOX2 to induce antigen-specific CD8+ cytotoxic T cells and Th1 CD4+ responses against NSCLC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
DNA Vaccines
drug_category
GENE THERAPY
drug_class
Vaccine
drug_delivery_route
Intradermal
drug_mechanism_of_action
Intradermal plasmid DNA vaccine encoding Th1-biased polyepitopes from CDH3, CD105, YB-1, MDM2, and SOX2 is taken up by antigen-presenting cells, leading to in situ expression, processing, and MHC I/II presentation. This primes antigen-specific CD8+ cytotoxic T cells and Th1 CD4+ helper responses to recognize and kill NSCLC cells expressing these antigens, enhancing tumor-specific cellular immunity.
drug_name
CD105/YB-1/SOX2/CDH3/MDM2 polyepitope plasmid DNA vaccine (STEMVAC)
nct_id_drug_ref
NCT05242965