drug_type
RELEVANT_DRUG
intervention_type
Drug (small-molecule dimerizer)
drug_description
Small-molecule dimerizer used to activate the inducible caspase-9 safety switch to rapidly eliminate CAR T cells in the event of toxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Rimiducid
drug_category
SMALL MOLECULE DRUG
drug_class
Other treatment
drug_delivery_route
Intravenous
drug_mechanism_of_action
Rimiducid (AP1903) is a small-molecule dimerizer that binds engineered FKBP12(F36V) domains fused to inducible caspase-9 in gene-modified T cells, inducing caspase-9 dimerization and activation, which triggers downstream caspase-3/7–mediated apoptosis to rapidly eliminate the modified cells as a safety switch in case of toxicity.
drug_name
AP1903 (rimiducid)
nct_id_drug_ref
NCT04715191