drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Autologous, genetically engineered T cells expressing a CD7-specific chimeric antigen receptor to recognize and eliminate CD7-positive malignant T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express a CD7-specific chimeric antigen receptor; upon binding CD7 on malignant T cells, CAR signaling activates the T cells to proliferate, release cytotoxic mediators, and lyse CD7-positive tumor cells independently of the native TCR.
drug_name
CD7-directed CAR-T cell therapy (RD13-02)
nct_id_drug_ref
NCT05979792