drug_type
RELEVANT_DRUG
intervention_type
cellular therapy (CAR T‑cell)
drug_description
Adoptive cellular therapy using engineered T cells (commonly CD19‑targeted) to mediate cytotoxicity against B‑cell malignancies.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Engineered autologous T cells expressing a chimeric antigen receptor (commonly targeting CD19) recognize B‑cell antigens independent of MHC, triggering T‑cell activation and cytotoxic killing of malignant B cells via perforin/granzyme release and cytokine production.
drug_name
CAR T‑cells (TBC)
nct_id_drug_ref
NCT05991388