drug_type
RELEVANT_DRUG
intervention_type
cellular therapy (CAR T)
drug_description
Adoptive cellular immunotherapy using T cells engineered with chimeric antigen receptors to target B-cell antigens.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express a chimeric antigen receptor that recognizes B-cell antigens (e.g., CD19/CD20). Antigen engagement triggers CAR signaling (CD3zeta plus costimulatory domains), leading to T-cell activation, proliferation, cytokine release, and MHC-independent cytotoxic killing of antigen-expressing B cells.
drug_name
CAR T-cell therapy
nct_id_drug_ref
NCT05852717