drug_type
RELEVANT_DRUG
intervention_type
Antibody–drug conjugate (ADC)
drug_description
Antibody–drug conjugate targeting TROP2 that is internalized and releases a topoisomerase I inhibitor payload to induce DNA damage and tumor cell death.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-targeted antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload, causing DNA damage and tumor cell death (with potential bystander effect).
drug_name
Sacituzumab tirumotecan (MK-2870/SKB264)
nct_id_drug_ref
NCT06445972