drug_type
RELEVANT_DRUG
intervention_type
bispecific antibody
drug_description
A bispecific antibody that binds CD3 on T cells and EGFR on tumor cells, bridging and activating T cells to kill EGFR-positive cancer cells; used ex vivo to arm autologous PBMCs prior to infusion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
A bispecific antibody that binds CD3 on T cells and EGFR on tumor cells, bridging them to activate and redirect T-cell cytotoxicity against EGFR-positive cancer cells. In this trial, autologous PBMCs are armed ex vivo with the bispecific before infusion to provide immediate T-cell engagement without genetic modification.
drug_name
anti-CD3 x anti-EGFR bispecific antibody
nct_id_drug_ref
NCT06479239