drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Patient-derived T cells engineered to express a chimeric antigen receptor targeting CD19 to trigger T-cell activation and cytotoxic killing of malignant B cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express a chimeric antigen receptor targeting CD19 on B cells; CD19 binding activates CAR signaling to trigger T-cell cytotoxicity and cytokine release, eliminating CD19-positive malignant B cells.
drug_name
Autologous anti-CD19 CAR T-cell therapy
nct_id_drug_ref
NCT05934838