drug_type
RELEVANT_DRUG
intervention_type
Biologic (bispecific antibody)
drug_description
Subcutaneous bispecific T‑cell–engaging antibody that binds CD3 on T cells and CD20 on B cells to form an immune synapse, activate TCR/CD3 signaling, and induce T‑cell–mediated cytotoxicity; used here with step‑up dosing around CAR‑T.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Epcoritamab
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Subcutaneous bispecific antibody that binds CD3 on T cells and CD20 on B cells, bringing them into proximity to form an immune synapse, activate TCR/CD3 signaling, and trigger T‑cell–mediated cytotoxicity (perforin/granzyme) against CD20+ B‑cell malignancies.
drug_name
Epcoritamab (GEN3013)
nct_id_drug_ref
NCT06458439