drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An anti-HER2 IgG1 antibody–drug conjugate linked to the microtubule inhibitor MMAE. It binds HER2 (ERBB2) on tumor cells, is internalized, and releases MMAE to disrupt tubulin polymerization, causing mitotic arrest and apoptosis; may also induce ADCC and bystander killing.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
disitamab vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-HER2 (ERBB2) IgG1 antibody–drug conjugate carrying the microtubule inhibitor MMAE. Upon binding HER2 on tumor cells, it is internalized and releases MMAE to inhibit tubulin polymerization, leading to G2/M arrest and apoptosis; may also engage Fc-mediated ADCC and enable bystander killing.
drug_name
Disitamab vedotin (RC48-ADC)
nct_id_drug_ref
NCT05940896