drug_type
RELEVANT_DRUG
intervention_type
Biologic (bispecific antibody adaptor)
drug_description
MicAbody adaptor protein (bispecific antibody; also known as ASP101G) that binds CD20 and carries an orthogonal NKG2D ligand to dock and activate ASP2802 convertible CAR T cells, enabling titratable on/off targeting.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
MA-20 (ASP101G) is a MicAbody bispecific adaptor that binds CD20 on B cells and carries an orthogonal NKG2D ligand to engage and activate ASP2802 convertible CAR T cells. By bridging CD20+ tumor cells to the engineered CAR T receptor, it enables titratable, on/off CAR T cytotoxic activity against CD20-positive malignancies.
drug_name
MA-20
nct_id_drug_ref
NCT06248086