drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
A HER2-targeted antibody–drug conjugate composed of a monoclonal antibody linked to the microtubule inhibitor MMAE (vedotin). It binds HER2 (including HER2-low), is internalized, and releases MMAE to disrupt microtubules causing mitotic arrest and apoptosis; Fc-mediated ADCC may also contribute.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
disitamab vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-directed antibody–drug conjugate that binds HER2 (including HER2-low), is internalized, and releases the microtubule inhibitor MMAE (vedotin) to disrupt tubulin polymerization, causing microtubule disruption, mitotic arrest, and apoptosis; Fc effector function may also mediate ADCC.
drug_name
Disitamab Vedotin (RC48-ADC)
nct_id_drug_ref
NCT06105008