drug_type
RELEVANT_DRUG
intervention_type
Biologic drug (monoclonal antibody; biosimilar)
drug_description
Pertuzumab biosimilar; a humanized anti-HER2 monoclonal antibody that binds HER2 subdomain II to block ligand-dependent HER2 dimerization (especially HER2/HER3), suppress downstream PI3K/AKT and MAPK signaling, and promote ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Pertuzumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Pertuzumab biosimilar; a humanized anti-HER2 monoclonal antibody that binds HER2 subdomain II to block ligand‑dependent HER2 dimerization (especially HER2/HER3), thereby suppressing downstream PI3K/AKT and MAPK signaling and eliciting antibody-dependent cellular cytotoxicity (ADCC).
drug_name
SYSA1901
nct_id_drug_ref
NCT05720026