drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Long-acting LS-engineered human IgG1 broadly neutralizing monoclonal antibody targeting the HIV-1 gp120 CD4-binding site to block attachment/entry; extended half-life via enhanced FcRn binding and may mediate Fc-effector functions (e.g., ADCC/ADCP).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal, Humanized
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Long-acting LS-engineered human IgG1 broadly neutralizing monoclonal antibody that binds the HIV-1 gp120 CD4-binding site, blocking attachment to CD4 and preventing viral entry; LS Fc modifications enhance FcRn binding to extend half-life and may enable Fc-mediated effector functions (e.g., ADCC/ADCP) against Env-expressing cells.
drug_name
VRC01.23LS
nct_id_drug_ref
NCT05959707