drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (anti-HER2)
drug_description
Anti-HER2 monoclonal antibody that inhibits HER2 signaling and mediates ADCC.
nci_thesaurus_concept_id
C1647
nci_thesaurus_preferred_term
Trastuzumab
nci_thesaurus_definition
A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. (NCI04)
drug_mesh_term
Trastuzumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized IgG1 monoclonal antibody targeting HER2/ERBB2; binds the extracellular domain on HER2-overexpressing tumor cells to block receptor signaling and dimerization, promote receptor downregulation, and engage Fc receptors to mediate antibody-dependent cell-mediated cytotoxicity (ADCC).
drug_name
Trastuzumab
nct_id_drug_ref
NCT05020860