drug_type
RELEVANT_DRUG
intervention_type
Biologic drug
drug_description
Polyclonal anti-T cell immunoglobulin used for T-lymphocyte depletion to reduce alloimmune responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antithymocyte Globulin
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Polyclonal anti–T‑cell immunoglobulin that binds multiple T‑lymphocyte surface antigens (e.g., CD2, CD3, CD4, CD8, CD25, HLA), triggering complement-dependent cytotoxicity, antibody‑dependent cellular cytotoxicity, and apoptosis, resulting in rapid T‑cell depletion and suppression of alloimmune responses.
drug_name
Antithymocyte globulin (ATG)
nct_id_drug_ref
NCT05973734