drug_type
RELEVANT_DRUG
intervention_type
Biological (broadly neutralizing monoclonal antibody)
drug_description
A human IgG1 broadly neutralizing monoclonal antibody engineered with an LS Fc mutation for extended half-life; binds the HIV-1 Env gp120 V2 apex to block viral entry and can mediate Fc-dependent effector functions (ADCC/ADCP).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Monoclonal Antibodies
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Human IgG1 broadly neutralizing monoclonal antibody with an LS Fc mutation for extended half-life (enhanced FcRn binding); binds the HIV-1 Env gp120 V2 apex to neutralize virions and block viral entry, and can engage Fc gamma receptors to mediate ADCC/ADCP against Env-expressing infected cells.
drug_name
PGDM1400LS
nct_id_drug_ref
NCT06508749