drug_type
RELEVANT_DRUG
intervention_type
Biological (broadly neutralizing monoclonal antibody)
drug_description
A human IgG1 broadly neutralizing monoclonal antibody engineered with an LS Fc mutation for extended half-life; recognizes the HIV-1 Env gp120 V3 glycan (N332) patch to neutralize virions and can mediate Fc-dependent effector functions.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Monoclonal Antibodies
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Human IgG1 broadly neutralizing monoclonal antibody with an LS Fc mutation for extended half-life that binds the HIV-1 Env gp120 V3 glycan (N332) patch to block viral attachment/entry and neutralize circulating virions; its Fc domain can engage Fc receptors to mediate ADCC/ADCP against Env-expressing infected cells.
drug_name
PGT121.414.LS
nct_id_drug_ref
NCT06508749