drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate (ADC)
drug_description
An anti‑HER2 antibody–drug conjugate consisting of a humanized anti‑HER2 monoclonal antibody linked to the microtubule inhibitor MMAE; kills HER2‑expressing tumor cells with a bystander effect.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-HER2 monoclonal antibody conjugated to the microtubule inhibitor MMAE. Binds HER2 on tumor cells, is internalized, and releases MMAE via a cleavable linker to disrupt microtubules, causing G2/M arrest and apoptosis; cytotoxic payload can diffuse for a bystander effect on neighboring cells with lower HER2 expression.
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT06112041