drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody
drug_description
IgG monoclonal antibodies targeting CD38 on myeloma cells, mediating ADCC/CDC and direct cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Unconjugated IgG monoclonal antibodies that bind CD38 on myeloma cells and induce Fc-mediated effector functions (antibody-dependent cellular cytotoxicity, antibody-dependent cellular phagocytosis, complement-dependent cytotoxicity) and direct apoptotic signaling, resulting in depletion of CD38-positive tumor and immunosuppressive cells.
drug_name
Anti-CD38 monoclonal antibodies
nct_id_drug_ref
NCT06205823