drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody
drug_description
IgG monoclonal antibodies targeting SLAMF7 to promote NK-cell–mediated cytotoxicity and immune activation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
General immune activator
drug_delivery_route
Intravenous
drug_mechanism_of_action
IgG monoclonal antibodies that bind SLAMF7 (CS1) on myeloma and NK cells, activating NK cells and promoting Fcγ receptor–mediated ADCC against SLAMF7+ tumor cells, with additional complement-dependent cytotoxicity and phagocytosis possible.
drug_name
Anti-SLAMF7 monoclonal antibodies
nct_id_drug_ref
NCT06205823