drug_type
RELEVANT_DRUG
intervention_type
Bispecific antibody
drug_description
Bispecific antibodies that bind GPRC5D on myeloma cells and CD3 on T cells to redirect cytotoxic T cells to tumor.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Not specified
drug_mechanism_of_action
Bispecific antibodies simultaneously bind GPRC5D on myeloma cells and CD3 on T cells, forming an immune synapse that activates and redirects cytotoxic T cells to kill GPRC5D-expressing tumor cells via perforin/granzyme release, independent of antigen presentation.
drug_name
GPRC5D×CD3 bispecific T-cell engagers
nct_id_drug_ref
NCT06205823