drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
Monoclonal antibodies targeting BCMA conjugated to cytotoxic payloads to deliver chemotherapy directly to myeloma cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
An anti-BCMA monoclonal antibody delivers a cytotoxic payload to BCMA-expressing myeloma cells. After binding BCMA and internalization, the linker is cleaved in the cell to release the toxin, causing microtubule disruption or DNA damage and inducing apoptosis; Fc-mediated effector functions may contribute.
drug_name
BCMA antibody-drug conjugates
nct_id_drug_ref
NCT06205823