drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T)
drug_description
Engineered allogeneic Vδ1 γδ CAR-T cell therapy targeting CD70 to recognize and kill CD70-expressing tumor cells in clear cell renal cell carcinoma.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Engineered allogeneic Vδ1 γδ T cells expressing a chimeric antigen receptor targeting CD70 on tumor cells. CAR engagement of CD70 triggers γδ T-cell activation, cytokine release, and cytotoxic killing of CD70-expressing clear cell renal cell carcinoma cells, with MHC-independent recognition enabling allogeneic use.
drug_name
ADI-270
nct_id_drug_ref
NCT06480565