drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Gene-modified autologous T lymphocytes expressing a chimeric antigen receptor targeting CD70; upon binding CD70 on tumor cells, they activate cytotoxic effector functions and proliferate to eradicate CD70-positive disease.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T lymphocytes genetically engineered to express a chimeric antigen receptor that binds CD70 on tumor cells; antigen engagement activates CAR signaling (CD3ΞΆ with costimulatory domains), driving T-cell proliferation, cytokine release, and perforin/granzyme-mediated cytotoxic killing of CD70-positive malignant cells.
drug_name
Autologous CD70-CAR T cells
nct_id_drug_ref
NCT06326463