drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody
drug_description
Anti-CD3 monoclonal antibody used to activate T cells during CIK cell expansion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Muromonab-CD3
drug_category
INHIBITORY ANTIBODY
drug_class
General immune activator
drug_delivery_route
Ex vivo (in vitro cell culture)
drug_mechanism_of_action
Muromonab-CD3 (OKT3) is a monoclonal antibody that binds the CD3ε chain of the T-cell receptor complex. Cross-linking triggers TCR signaling, causing rapid T-cell activation and proliferation; prolonged engagement can lead to activation-induced cell death and Fc-mediated depletion. In this study it is used ex vivo to polyclonally activate T cells during CIK expansion.
drug_name
OKT3 (muromonab-CD3)
nct_id_drug_ref
NCT06684899