drug_type
RELEVANT_DRUG
intervention_type
Allogeneic, gene-engineered adoptive cellular therapy (biologic)
drug_description
Allogeneic, gene-engineered universal T cells expressing chimeric natural killer (NK) receptors, administered intravenously to harness NK receptor–mediated recognition and signaling on T cells for cytotoxic and immunomodulatory activity to dampen the pathogenic immune response in steroid-refractory or -dependent acute GVHD.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic gene‑engineered universal T cells expressing chimeric NK receptors recognize stress‑induced ligands on pathogenic immune cells via NK receptor–derived recognition domains and signal through T‑cell activation domains to exert cytotoxic and immunomodulatory effects, depleting or suppressing alloreactive cells and inflammatory pathways that drive steroid‑refractory/dependent acute GVHD.
drug_name
Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
nct_id_drug_ref
NCT06750133