drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T-cell therapy)
drug_description
Autologous T lymphocytes genetically engineered to express a chimeric antigen receptor specific for CD70; upon binding CD70 on tumor cells, they activate, proliferate, and mediate cytolysis and cytokine release.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T lymphocytes engineered to express a CD70-specific chimeric antigen receptor; binding to CD70 on tumor cells activates the T cells, leading to proliferation, perforin/granzyme-mediated cytolysis, and cytokine release to eliminate CD70-expressing cancer cells.
drug_name
CD70-targeted CAR T cells
nct_id_drug_ref
NCT05947487