drug_type
RELEVANT_DRUG
intervention_type
Gene therapy (viral vector)
drug_description
An adenoviral vector-based gene therapy delivering an hTERT-targeted trans-splicing ribozyme to redirect hTERT mRNA to express HSV-1 thymidine kinase selectively in tumor cells, enabling suicide gene therapy.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Viral Vectors
drug_category
GENE THERAPY
drug_class
Gene therapy
drug_delivery_route
Unknown
drug_mechanism_of_action
A replication-deficient adenoviral vector delivers an hTERT-targeted trans-splicing ribozyme that redirects hTERT mRNA to express HSV-1 thymidine kinase selectively in tumor cells. Upon administration of valganciclovir, HSV-TK converts it into cytotoxic nucleotides, inducing tumor cell death with bystander and immunogenic effects (suicide gene therapy).
drug_name
RZ-001
nct_id_drug_ref
NCT06695026