drug_type
RELEVANT_DRUG
intervention_type
cellular immunotherapy (dendritic cell vaccine)
drug_description
Autologous CD141+ dendritic cell vaccine engineered to present the WT1 tumor antigen, aiming to cross-prime and expand WT1-specific CD8+ T-cell cytotoxic responses against pancreatic cancer.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cancer Vaccines
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous CD141+ dendritic cells engineered to present WT1 antigen prime and cross-prime T cells by displaying WT1 peptides on MHC I/II, expanding WT1-specific CD8+ cytotoxic and CD4+ helper T-cell responses to target and kill WT1-expressing pancreatic cancer cells.
drug_name
CellgramDC-WT1 (autologous bone marrow-derived dendritic cell vaccine)
nct_id_drug_ref
NCT06172634