drug_type
RELEVANT_DRUG
intervention_type
Cellular Therapy
drug_description
Engineered CAR T cells (lentiviral) targeting cytomegalovirus glycoprotein B (gB); dose-escalated IV infusion; designed for MHC-independent cytotoxicity against gB-expressing CMV-associated tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Lentiviral-engineered T cells expressing a chimeric antigen receptor targeting cytomegalovirus glycoprotein B (gB); upon gB binding, the CAR drives MHC-independent T-cell activation and cytotoxicity (perforin/granzyme release and cytokine-mediated killing) against gB-expressing CMV-associated tumor cells.
drug_name
CMV gB-directed CAR T cells
nct_id_drug_ref
NCT06849921