drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous T cells engineered to express a chimeric antigen receptor targeting CD19 to induce MHC-independent T-cell activation, proliferation, cytokine release, and cytotoxic killing of CD19-positive malignant B cells.
nci_thesaurus_concept_id
C176018
nci_thesaurus_preferred_term
Anti-CD19 CAR T Cells Preparation
nci_thesaurus_definition
Any preparation of CAR-T cells that targets CD19.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express an anti-CD19 chimeric antigen receptor bind CD19 on B cells, triggering MHC-independent activation via CD3z and costimulatory domains, leading to T-cell expansion, cytokine release, and cytotoxic killing of CD19-positive malignant B cells.
drug_name
Anti-CD19 CAR T cells
nct_id_drug_ref
NCT06756321