drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
HER2-targeted antibody–drug conjugate in which trastuzumab binds HER2, inhibits HER2 signaling and mediates ADCC; internalization releases the DM1 maytansinoid microtubule inhibitor, causing mitotic arrest and cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Ado-Trastuzumab Emtansine
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted monoclonal antibody–drug conjugate: trastuzumab binds HER2, inhibits HER2 signaling and mediates ADCC; upon receptor-mediated internalization, the DM1 (maytansinoid) microtubule inhibitor is released, disrupting microtubules to induce mitotic arrest and tumor cell death.
drug_name
Trastuzumab emtansine (T-DM1)
nct_id_drug_ref
NCT06481956