drug_type
RELEVANT_DRUG
intervention_type
Biological: Cellular immunotherapy
drug_description
Allogeneic gamma-delta T cells engineered to express an anti-CD19 chimeric antigen receptor, enabling MHC-independent cytotoxic depletion of CD19+ B cells to reset the B-cell compartment and reduce autoantibody-driven inflammation in SLE.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic gamma-delta T cells engineered with an anti-CD19 chimeric antigen receptor recognize CD19 on B cells and mediate MHC-independent cytotoxic killing, depleting CD19+ B-cell subsets to reset the B-cell compartment and reduce autoantibody-driven inflammation in SLE.
drug_name
CD19 Universal CAR-γδ T Cells
nct_id_drug_ref
NCT06106893