drug_type
RELEVANT_DRUG
intervention_type
Biological; gene-modified T-cell therapy (CAR-T)
drug_description
Universal (allogeneic) chimeric antigen receptor T cells targeting CD19 to deplete naïve, memory, and activated B cells, aiming to suppress humoral immunity in lupus nephritis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic gene-modified T cells expressing a CD19-directed chimeric antigen receptor bind CD19 on B-lineage cells and trigger cytotoxic killing (perforin/granzyme), depleting naive, memory, and activated B cells to suppress humoral immunity and reduce autoantibody production in lupus nephritis.
drug_name
CD19 CAR-T cells
nct_id_drug_ref
NCT06681337