drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
An antibody-drug conjugate targeting integrin beta-6 (ITGB6) that is internalized into tumor cells and releases the microtubule inhibitor monomethyl auristatin E (MMAE), leading to microtubule disruption and tumor cell death.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody targets integrin beta-6 (ITGB6) on tumor cells, is internalized, and releases the cytotoxic payload monomethyl auristatin E (MMAE). Released MMAE inhibits tubulin polymerization, disrupting microtubules, inducing mitotic arrest, and causing tumor cell death.
drug_name
sigvotatug vedotin (SGN-B6A)
nct_id_drug_ref
NCT06549816