drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
AMG 451; a subcutaneous afucosylated IgG1 monoclonal antibody that targets OX40 (CD134), blocking OX40/OX40L costimulatory signaling and depleting OX40-positive activated T cells via ADCC to reduce sustained T-cell activation and type 2 inflammation.
nci_thesaurus_concept_id
C184936
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Afucosylated IgG1 monoclonal antibody targeting OX40 (CD134) that blocks OX40/OX40L costimulatory signaling and depletes OX40-positive activated T cells via enhanced ADCC, reducing sustained T-cell activation and type 2 inflammatory responses.
drug_name
Rocatinlimab
nct_id_drug_ref
NCT06527404