drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous anti-CD19 chimeric antigen receptor T-cell therapy that recognizes CD19 on malignant B cells, activates T cells, and mediates cytotoxic killing.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
axicabtagene ciloleucel
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous anti-CD19 chimeric antigen receptor T cells that recognize CD19 on malignant B cells, activate and expand upon engagement, and mediate cytotoxic killing of CD19-positive cells via perforin/granzyme pathways and cytokine-driven immune responses.
drug_name
Axicabtagene ciloleucel (axi-cel)
nct_id_drug_ref
NCT05757219