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drug_type
RELEVANT_DRUG
intervention_type
Cellular immunotherapy (biological)
drug_description
A biological, cell-based immunotherapy administered by intravenous infusion at 3.0×10^8 or 6.0×10^8 cells (up to three monthly infusions) for refractory colorectal or pancreatic cancer; intended to elicit immune-mediated antitumor cytotoxicity. Specific cell type/engineering and target antigens are not disclosed.
nci_thesaurus_concept_id
C198216
nci_thesaurus_definition
A preparation of human T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for two as of yet undisclosed tumor-associated antigens (TAAs), with potential immunostimulating and antineoplastic activities. Upon administration, the dual-target CAR-T cells BGT007 specifically recognize and induce selective toxicity in tumor cells expressing the two TAAs.
drug_mesh_term
Cell- and Tissue-Based Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Genetically modified human T lymphocytes engineered to express a chimeric antigen receptor that recognizes two undisclosed tumor-associated antigens. Upon binding antigen on colorectal or pancreatic tumor cells, the CAR activates T-cell effector functions (cytokine release, proliferation, and perforin/granzyme-mediated lysis), producing selective immune-mediated antitumor cytotoxicity and aiming to reduce antigen-escape through dual targeting.
drug_name
BGT007
nct_id_drug_ref
NCT06645301