drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR-T)
drug_description
Murine-derived, second-generation chimeric antigen receptor T cells targeting CD19 with 4-1BB costimulation for targeted killing and T-cell persistence.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express a murine-derived anti-CD19 chimeric antigen receptor with 4-1BB costimulation and CD3z signaling; upon binding CD19 on B cells, the CAR triggers MHC-independent T-cell activation, proliferation, cytokine release, and cytolytic killing, with 4-1BB enhancing T-cell persistence.
drug_name
CD19 CAR-T cells
nct_id_drug_ref
NCT06481228