drug_type
RELEVANT_DRUG
intervention_type
Cellular gene therapy (CAR T cells)
drug_description
Patient-derived T cells engineered (retroviral transduction) to express an anti-CD7 chimeric antigen receptor; cellular gene therapy targeting CD7+ T/NK cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered (retroviral transduction) to express an anti‑CD7 chimeric antigen receptor. Engagement of CD7 on target T- and NK-lineage cells activates the CAR T cells, inducing perforin/granzyme-mediated cytotoxicity and inflammatory cytokine release, resulting in selective depletion of CD7+ cells and immune reset.
drug_name
Autologous CD7-directed CAR-T cells
nct_id_drug_ref
NCT07139600