drug_type
RELEVANT_DRUG
intervention_type
immunosuppressive antibody
drug_description
Rabbit polyclonal antilymphocyte globulin used for in vivo T-cell depletion to reduce graft-versus-host disease risk.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antilymphocyte Serum
drug_category
CYTOTOXIC ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Rabbit polyclonal IgG against multiple human T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA) that depletes T lymphocytes via complement-dependent cytotoxicity, Fc-mediated ADCC/phagocytosis, and apoptosis, producing in vivo T‑cell immunosuppression to reduce GVHD risk.
drug_name
Rabbit anti-thymocyte globulin (rATG)
nct_id_drug_ref
NCT06158828