drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (anti-CD52)
drug_description
Anti-CD52 monoclonal antibody that depletes CD52-positive immune cells (T, B, NK) to reduce rejection of allogeneic CAR T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Unconjugated anti-CD52 monoclonal antibody that binds CD52 on T, B, and NK cells and depletes them via Fc-mediated effector functions (ADCC/CDC), achieving lymphodepletion to reduce host rejection of allogeneic CAR T cells.
drug_name
ALLO-647
nct_id_drug_ref
NCT06500273