drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Individualized neoantigen mRNA cancer vaccine that encodes patient-specific tumor neoantigens; after intramuscular injection, APCs (especially dendritic cells) translate the mRNA and present peptides on MHC I/II to prime and expand tumor-specific CD8+ and CD4+ T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
RNA Vaccines
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Individualized mRNA vaccine encoding patient-specific tumor neoantigens. After intramuscular injection, antigen-presenting cells (notably dendritic cells) take up the mRNA, translate it into neoantigen proteins, and present peptides on MHC I and II to prime and expand tumor-specific CD8+ cytotoxic and CD4+ helper T cells, driving anti-tumor immunity.
drug_name
InnoPCV
nct_id_drug_ref
NCT06497010