drug_type
RELEVANT_DRUG
intervention_type
Biological (CAR T-cell therapy)
drug_description
Off-the-shelf allogeneic, gene-modified T cells engineered with a lentiviral CD7-directed chimeric antigen receptor to recognize and kill CD7-positive malignant T/NK lineage cells; designed for persistence to control CD7+ disease.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic gene‑modified T cells engineered with a lentiviral CD7‑specific chimeric antigen receptor that binds CD7 on malignant T/NK lineage cells, triggering CAR‑mediated activation, proliferation, cytokine release, and perforin/granzyme‑dependent cytotoxic killing independent of the native TCR; designed for persistence to control CD7‑positive disease.
drug_name
Universal 4SCAR7U CD7-specific CAR T cells
nct_id_drug_ref
NCT05995028