drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
A HER2-directed antibody–drug conjugate composed of a humanized anti-HER2 monoclonal antibody linked via a cleavable linker to monomethyl auristatin E (MMAE); binds ERBB2/HER2, is internalized, and releases MMAE to inhibit microtubule polymerization, causing mitotic arrest and apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-directed antibody–drug conjugate: the anti-HER2 monoclonal antibody binds ERBB2/HER2, is internalized, and via a cleavable linker releases MMAE, which inhibits microtubule polymerization, causing G2/M arrest and apoptosis (potential bystander cytotoxicity).
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT06574763