drug_type
RELEVANT_DRUG
intervention_type
cellular therapy (CAR T cells)
drug_description
Autologous T cells engineered with a chimeric antigen receptor to recognize and kill malignant B cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express a chimeric antigen receptor that binds B-cell surface antigens (e.g., CD19) independent of HLA, activating T-cell signaling, proliferation, and cytotoxicity to eliminate malignant B cells via perforin/granzyme release and cytokine-mediated killing.
drug_name
CAR-T
nct_id_drug_ref
NCT06504199