drug_type
RELEVANT_DRUG
intervention_type
Drug: Antibody-Drug Conjugate
drug_description
An antibody-drug conjugate targeting mesothelin (MSLN). The monoclonal antibody binds MSLN on tumor cells, is internalized, and releases a cytotoxic payload intracellularly to induce tumor cell death, with potential bystander effect.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody targets mesothelin (MSLN) on tumor cells, is internalized, and releases an attached cytotoxic payload inside the cell to induce tumor cell death, with potential bystander killing of adjacent cells.
drug_name
PF-08052666 (SGN-MesoC2; HBM9033)
nct_id_drug_ref
NCT06466187