drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR-NKT cells)
drug_description
CD70-targeted CAR–NKT cell therapy: autologous natural killer T cells genetically engineered to express an anti-CD70 chimeric antigen receptor; designed to recognize CD70 on tumor cells and mediate cytotoxicity and cytokine release.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
T-Lymphocytes, NKT
drug_category
OTHER ENGINEERED IMMUNE CELL
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous natural killer T cells engineered with an anti-CD70 chimeric antigen receptor bind CD70 on tumor cells, triggering CAR signaling that activates NKT-mediated cytotoxicity (perforin/granzyme) and proinflammatory cytokine release (e.g., IFN-γ, TNF-α), resulting in TCR-independent lysis of CD70-positive cancer cells and amplification of anti-tumor immunity.
drug_name
CGC738
nct_id_drug_ref
NCT06728189